Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones
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چکیده
منابع مشابه
Enhancement of potassium-sensitive current in heart cells by pinacidil. Evidence for modulation of the ATP-sensitive potassium channel.
Pinacidil belongs to a novel group of compounds that enhance the potassium permeability of vascular smooth muscle. Evidence also exists that this drug enhances the potassium permeability of cardiac tissue. The purpose of the present investigation was to determine if pinacidil alters potassium-channel activity in heart and, if so, which potassium channel is the target. We used the whole-cell arr...
متن کاملEffect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.
OBJECTIVES The purpose of this study was to determine whether ATP-sensitive potassium (K(ATP)) channel agonists exert a beneficial effect on the structural, functional, and molecular features of the remodeling heart in infarcted rats. BACKGROUND Myocardial K(ATP) channels have been implicated in the ventricular remodeling after myocardial infarction by inhibition of 70-kDa S6 (p70S6) kinase. ...
متن کاملEffect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Although the acute administration of ATP-sensitive potassium (K(ATP)) channel agonists provides a neuroprotection, it is unclear whether similar benefits are found by modulating sympathetic innervation in chronic settings after myocardial infarction. We assessed whether K(ATP) channel agonists can attenuate the sprouting of cardiac sympathetic nerves after infarction. Male Wistar rats after lig...
متن کاملIdentification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.
Protection of heart against ischemia-reperfusion injury by ischemic preconditioning and K(ATP) channel openers is known to involve the mitochondrial ATP-sensitive K(+) channel (mitoK(ATP)). Brain is also protected by ischemic preconditioning and K(ATP) channel openers, and it has been suggested that mitoK(ATP) may also play a key role in brain protection. However, it is not known whether mitoK(...
متن کاملCardioprotective effects mitochondrial ATP-sensitive potassium channel in exercise conditioning.
We investigated the mitochondrial ATP-sensitive potassium channel [mito-K (ATP)] in exercise preconditioning of myocardial ischemia-reperfusion injury in rats. Eighty SD rats were randomly divided into high-, moderate-, low-intensity, and control groups. The exercise groups were divided into control and inhibited groups. The control group was divided into model and sham groups. Eight rats were ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1998
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1998.441bk.x